Implantable Loop Recorder and Cardioneuroblation

Inclusion Criteria: * Age 18 to 60 years * Clinical diagnosis of reflex syncope as per class I criteria of the ESC guidelines * History of recurrent severe syncopes (≥2 in the last year or ≥3 in the last 2 years), significantly affecting the quality of life, nonresponding to lifestyle measures. * Documentation by means of prolonged ECG monitoring of an asystolic pause \>6 sec or of an asystolic syncope \>3 sec and/or an asystolic syncope induced during tilt testing (Vasis 2B form). Exclusion Criteria: * Intrinsic sinus dysfunction or atrioventricular node disease. * Constitutional hypotension and orthostatic intolerance syndromes * Overt structural heart disease * Alternative diagnoses of syncope * Pregnancy or breastfeeding