Polymeric Micellar Paclitaxel-Based Combination Therapy for Advanced Biliary Tract Cancer

Inclusion Criteria: * The subjects voluntarily participated in the study, provided written informed consent, and were willing to comply with study treatment, assessments, and follow-up. Patients were ≥18 years old and \<75 years old at the time of signing informed consent, regardless of gender. * Patients with advanced biliary tract carcinoma diagnosed by imaging and histology as unresectable, recurrent, locally advanced, or metastatic disease, defined as stage IIIA or above according to the AJCC 8th edition staging system, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer. No more than two metastatic organ sites were allowed, including liver, lung, bone, and brain. * Radical surgery or local treatment, including focal excision, ablation, transcatheter arterial chemoembolization, hepatic arterial infusion chemotherapy, and radiotherapy, was not appropriate, or disease progression occurred after local treatment. At least 4 weeks should have elapsed after local treatment before baseline assessment, and acute toxicities related to prior treatment should have recovered to NCI-CTCAE version 5.0 grade 1 or lower. * Patients had disease progression after, or intolerance to, first-line systemic therapy for at least 1 month and required subsequent palliative systemic treatment. Treatment-related adverse events should have recovered to NCI-CTCAE version 5.0 grade 1 or lower before enrollment. * At least one measurable lesion according t…