Efficacy of Methylprednisolone for Pain Control After ACL Repair (NCT07158476) | Clinical Trial Compass
RecruitingPhase 4
Efficacy of Methylprednisolone for Pain Control After ACL Repair
United States90 participantsStarted 2025-10-21
Plain-language summary
Opioids are commonly used after orthopedic surgery for pain control but have been shown to increase complications, surgeries, readmissions, and risk for opioid use disorder. The purpose of this study is to investigate the impact of adding a methylprednisolone taper to the pain regimen after ACL repair surgery to determine if this results in decreased postoperative pain and opioid use without increasing complications.
Who can participate
Age range13 Years – 50 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patient undergoing ACL repair or ACL reconstruction with tendon autograft
* Age 13-50 years old
* Able to provide informed consent or parent/legal guardian is able for minors
Exclusion Criteria:
* Concurrent and significant injury to other bones or organs (Injury Severity Score of 4 or greater)
* Revision ACL reconstruction
* Concomitant additional ligament reconstruction or high tibial osteotomy
* A history of alcohol abuse, substance abuse or chronic opioid use (filled opioid medication ×2 within 6 months of the surgery)
* A history of renal failure (\<60 mL/min/1.73 m2), liver dysfunction (child class, \>B), severe heart disease (NYHA Class 4), diabetes, neurological or psychiatric diseases that may affect pain perception, and pre-existing immune suppression.
* A history or active peptic ulcer disease, gastrointestinal bleeding, or current use of anticoagulation.
* Patients currently taking oral or injectable glucocorticoids and those who have taken either within 1 month of the procedure.
* Patients who are currently pregnant.
* Patients who are unable to undergo the multimodal pain standardized protocol including those with comorbidities or medical allergies precluding the use of corticosteroids, gabapentin, hydrocodone, acetaminophen, ketorolac, and/or meloxicam.
What they're measuring
1
Numerical Rating Scale (NRS) pain scores
Timeframe: Post-op days 0-14, 2 weeks, 6 weeks, and 12 weeks