The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the pathogenesis of periodontal disease in individuals with psoriasis, thereby revealing immunological and neuroendocrine interactions. The fundamental question it aims to answer is: What are the biological mechanisms that may increase the risk of periodontal disease in individuals with psoriasis? In this context, the periodontal status of individuals with psoriasis will be clinically assessed, followed by analysis of the levels of Th17-associated cytokines and stress biomarkers in gingival crevicular fluid and saliva samples. Additionally, patients will be asked questions from the Social Appearance Anxiety Scale. The periodontal status of individuals with psoriasis will be determined cross-sectionally, and the resulting biomarker levels will be examined. In addition, the data obtained will be evaluated with statistical analysis in relation to disease severity and clinical parameters.
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Gingival Crevicular Fluid (GCF) Collection
Timeframe: Day 1
Saliva sampling
Timeframe: Day 1
Clinical Periodontal Parameters (Plaque Index)
Timeframe: Day 1
Clinical Periodontal Parameters (Gingival Index)
Timeframe: Day 1
Periodontal Clinical Parametres (Bleeding on Probing Index)
Timeframe: Day 1
Periodontal Clinical Parametres (Probing Pocket Depth)
Timeframe: Day 1
Periodontal Clinical Parametres (Clinical Attachment Loss)
Timeframe: Day 1
Application of the Social Appearance Anxiety Scale
Timeframe: Day 1