Pathogenesis of Periodontal Disease in Individuals With Psoriasis (NCT07158125) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Pathogenesis of Periodontal Disease in Individuals With Psoriasis
Turkey (Türkiye)60 participantsStarted 2025-09-15
Plain-language summary
The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the pathogenesis of periodontal disease in individuals with psoriasis, thereby revealing immunological and neuroendocrine interactions.
The fundamental question it aims to answer is:
What are the biological mechanisms that may increase the risk of periodontal disease in individuals with psoriasis?
In this context, the periodontal status of individuals with psoriasis will be clinically assessed, followed by analysis of the levels of Th17-associated cytokines and stress biomarkers in gingival crevicular fluid and saliva samples. Additionally, patients will be asked questions from the Social Appearance Anxiety Scale. The periodontal status of individuals with psoriasis will be determined cross-sectionally, and the resulting biomarker levels will be examined. In addition, the data obtained will be evaluated with statistical analysis in relation to disease severity and clinical parameters.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Being between the ages of 18 and 65
* Being diagnosed with psoriasis by a dermatologist
* Having at least 20 teeth
* Not having received periodontal treatment in the last 6 months
* Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks
* Not having any autoimmune disease, osteoporosis, or cancer
* Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates
* Not being pregnant
* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)
* Not using chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)
* Not having taken antioxidant supplements in the last 6 months
Exclusion Criteria:
* \<20 teeth
* Any significant oral infection (i.e., herpes or candidiasis)
* Oral injuries or bleeding unrelated to periodontitis
* Periodontal therapy and antibiotic therapy within the past 3 months
* Salivary gland dysfunction
* Acute illness (fever, sore throat)
* Systemic illness, mental illness, immunosuppressive drugs or immunodeficiency
* Pregnancy or breastfeeding
* Use of antidepressants
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Gingival Crevicular Fluid (GCF) Collection
Timeframe: Day 1
2
Saliva sampling
Timeframe: Day 1
3
Clinical Periodontal Parameters (Plaque Index)
Timeframe: Day 1
4
Clinical Periodontal Parameters (Gingival Index)
Timeframe: Day 1
5
Periodontal Clinical Parametres (Bleeding on Probing Index)