This is a clinical trial using an up-and-down sequential design, aiming to investigate the median effective dose (ED50) and 95% effective dose (ED95) of oliceridine for inhibiting hyperdynamic responses induced by tracheal intubation during general anesthesia induction. The study will enroll patients undergoing elective tracheal intubation under general anesthesia, stratified into young (18-65 years) and elderly (≥65 years) groups. By dynamically adjusting oliceridine doses, the optimal induction dose in different age groups will be evaluated to provide reference for rational clinical medication.
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ED₉₅ of oliceridine for suppression of tracheal intubation-induced hemodynamic response
Timeframe: From the start of intubation to 3 minutes after the end of intubation
EDâ‚…â‚€ of oliceridine for suppression of tracheal intubation-induced hemodynamic response
Timeframe: From the start of intubation to 3 minutes after the end of intubation