A Novel Insight Into CRPC Progression and Immune: Evidence From Single-cell Spatial Transcriptome… (NCT07154914) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
A Novel Insight Into CRPC Progression and Immune: Evidence From Single-cell Spatial Transcriptome Multi-omics
396 participantsStarted 2025-09-01
Plain-language summary
This study will follow patients with metastatic hormone-sensitive prostate cancer (mHSPC) who receive androgen deprivation therapy (ADT) combined with different treatments. Prostate cancer is a common cancer in men, and many patients in China are diagnosed at an advanced stage. While ADT alone has been the standard treatment, most patients eventually progress to castration-resistant disease.
New medicines such as abiraterone, enzalutamide, apalutamide, darolutamide, and chemotherapy like docetaxel have shown survival benefits when added to ADT. This study aims to observe how different ADT-based combinations work in real-world practice and whether genetic differences affect outcomes.
About 396 patients will be enrolled and followed until disease progression or death. The results will help identify which treatments are most effective and guide more personalized care for men with advanced prostate cancer.
Who can participate
Age range18 Years – 85 Years
SexMALE
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Inclusion criteria
✓. Male patients, age \>18 and \<85 years.
✓. Histologically confirmed prostate adenocarcinoma, ductal adenocarcinoma, or intraductal carcinoma.
✓. Evidence of distant metastases by imaging (according to RECIST criteria).
✓. No prior systemic therapy for prostate cancer (no ADT or other systemic treatments).
✓. ECOG performance status 0-2 and estimated life expectancy \>6 months.
✓. Adequate organ function as indicated by:
✓. Ability to provide written informed consent.
Exclusion criteria
✕. Histological diagnosis of neuroendocrine or small-cell prostate cancer.
✕. No evidence of distant metastases on imaging.
✕. Prior systemic therapy for prostate cancer (neoadjuvant, adjuvant, or systemic).
What they're measuring
1
Time to progression to castration-resistant prostate cancer (CRPC)