GLP-1R Actions on Muscle and the Skeleton

Inclusion Criteria: * Subjects will have a BMI between 30kg/m2 * 40kg/m2 (inclusive) * Be between 18 and 50 years of age (inclusive). * Non-Hispanic Black males and females will be enrolled at PBRC. * Rural males and females will be enrolled at MaineHealth. * Female subjects will be premenopausal. * Females have had their last menstrual period less than 60 days before screening. * Females have the absence of menopausal-associated vasomotor symptoms. * All subjects must be able to use Lifestyle Toolkit as prescribed for intervention arm. Exclusion Criteria: \- Males and females over the age of 50 years of age * Menopausal females. * Subjects on systemic corticosteroids or other agents known to increase loss of muscle and bone mass. * Subjects who are on medications that increase or decrease weight status. * Subjects having contraindications to tirzepatide in the package insert. * Subjects with a history of malignancy other than non-melanoma skin cancer * Subjects with known osteoporosis or are on osteoporosis therapies (gonadal hormones or hormone antagonists). * Subjects with uncontrolled thyroid or parathyroid disease that may influence the study results. * Subjects with a clinically significant hematologic abnormality, kidney disease, liver disease, or diabetes. * Females of childbearing potential who do not agree to using an effective method of contraception during the study. Medically acceptable methods include oral contraceptive medication, an intrauterine device …