Small Bites Vs Large Bites Abdominal Midline Incisional Closure (NCT07154277) | Clinical Trial Compass
Active — Not RecruitingPhase 2/3
Small Bites Vs Large Bites Abdominal Midline Incisional Closure
Pakistan200 participantsStarted 2023-11-23
Plain-language summary
The goal of this trial is to compare the effectiveness of small bite versus large bite abdominal incision closure in emergency settings. It will also evaluate the safety and outcomes of each technique. The main questions it aims to answer are:
Does small bite closure reduce the incidence of superficial surgical site infections (SSI), wound dehiscence, and incisional hernia compared to large bite closure? What are the associated complications of each closure technique?
Participants will:
Undergo either a small bite or large bite abdominal incision closure during emergency laparotomy Visit the clinic for follow-up assessments at 7 days, 15 days, 1 month, 3 months, and 6 months post-operatively Have their wound healing and complications documented and analyzed during respective visits.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults ages in between 18-60 year old
* All emergency laparotomies (Except trauma)
Exclusion Criteria:
* Previous surgery with midline incision
* Pregnancy
* Current immunosuppressive or chemotherapy
* Previous incisional hernia after midline incision
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing 'small bites' versus 'large bites' suture techniques for closing abdominal incisions — can you explain what that difference actually means in practice, and whether the technique used to close my incision could affect my risk of the wound reopening or getting infected?
2Since this is a Phase 2/3 trial focused on preventing wound dehiscence and surgical site infections, what do we currently know about whether one closure technique is safer or more effective than the other, and is there already a standard approach you'd use for my surgery?
3The trial is active but no longer recruiting new participants — does that mean the results might be available soon, and could those findings influence which closure technique you'd use for me even if I'm not enrolled?
4Given that this trial is specifically measuring wound reopening and infection rates, how significant are those risks for the type of abdominal surgery I need, and what factors about my health might put me at higher or lower risk for those complications regardless of which technique is used?
5Are there other aspects of my recovery or my individual health history — like previous abdominal surgeries, weight, or diabetes — that would make one suture closure technique more appropriate for me than the other, based on what's already known outside of this trial?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number of participants with Wound Dehiscence
Timeframe: 1 month
2
Number of participants with Surgical Site Infections