By InvitationPhase 4

Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty

United States560 participantsStarted 2026-02-02

Plain-language summary

The purpose of this study is to evaluate the effectiveness and safety of tramadol and oxycodone therapy in comparison to oxycodone alone as part of a multimodal pain regimen to reduce postoperative opioid consumption, pain, minimize adverse events and complications for primary total knee arthroplasty (TKA) and primary total hip arthroplasty (THA).

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Primary TKA * Primary THA * Age \> 18 years Exclusion Criteria: * Age \< 18 years * Revision or partial TKA/THA * Pregnant or breast-feeding women * Simultaneous bilateral TKA/THA * Primary TKA/THA due to oncologic reason * Anaphylaxis to opioids * Renal or liver failure * Prior opioid use disorder/ substance use disorder * Opioid use within 3 months prior to surgery * Patients needing a translator and those with dementia or other cognitive deficits * Patients taking Monoamine Oxidase Inhibitor (MOAI) medications (phenelzine, tranylcypromine) or benzodiazepine medications (alprazolam, diazepam, lorazepam, etc)

What they're measuring

Cumulative opioid consumption during the first 30 days

Timeframe: 30 days

Trial details

NCT IDNCT07153003

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-09-01

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