RecruitingNot Applicable

The Diagnostic Value of Subharmonic Imaging Technology Combined With Liver Stiffness and Platelet Count for High-risk Esophageal and Gastric Varices in Patients With Liver Cirrhosis

China380 participantsStarted 2025-08-31

Plain-language summary

To evaluate the diagnostic value of the combined model of subharmonic-assisted pressure estimation (SHAPE), liver stiffness (LSM), and platelet count (PLT) for high-risk esophageal and gastric varices (HRV)

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ① Be at least 18 years old② Clinically diagnosed as liver cirrhosis (based on medical history, physical signs, laboratory tests, imaging or liver biopsy)③ Underwent a gastroscopy④ The informed consent form has been signed Exclusion Criteria: * ① Previous EV bleeding or having received TIPS/ endoscopic treatment.② History of concurrent liver cancer, portal vein thrombosis, and splenectomy.③ Having used drugs that affect platelet count, liver function or coagulation function in the body within one week, and having a recent history of blood product infusion.

What they're measuring

HV-PV (dB)

Timeframe: Within two weeks of admission

Measurement of liver stiffness（kPa）

Timeframe: Within two weeks of admission

blood platelet count（×10⁹／L）

Timeframe: Within two weeks of admission

sensitivity and specificity

Timeframe: The one-year period from enrollment to the end of the group

Positive predictive value (PPV) and negative predictive value (NPV)

Timeframe: The one-year period from enrollment to the end of the group

AUC

Timeframe: The one-year period from enrollment to the end of the group

Trial details

NCT IDNCT07151885

SponsorThe First Hospital of Jilin University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-07-31

Contact for this trial

Dezhi Zhang, doctorate

0431-88782190 dezhi@jlu.edu.cn

View on ClinicalTrials.gov More Liver Cirrhosis trials

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

HV-PV (dB)

Timeframe: Within two weeks of admission

Measurement of liver stiffness（kPa）

Timeframe: Within two weeks of admission

blood platelet count（×10⁹／L）

Timeframe: Within two weeks of admission

sensitivity and specificity

Timeframe: The one-year period from enrollment to the end of the group

Positive predictive value (PPV) and negative predictive value (NPV)

Timeframe: The one-year period from enrollment to the end of the group

AUC

Timeframe: The one-year period from enrollment to the end of the group