CompletedNot Applicable

Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study

United States12 participantsStarted 2025-09-18

Plain-language summary

This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a blood marker of cognitive decline. The changes in p-tau concentrations after exposure to WRAP will be compared to the changes in p-tau after exposure to clean air. Participants will: * Have 2 study visits - one visit with exposure to clean air and one visit with exposure to simulated wildfire smoke * Have blood drawn before and after each exposure * Complete cognitive tests and memory tasks before and after each exposure

Who can participate

Age range18 Years – 40 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy * Non smoker * Weight at least 110 pounds * Between ages 18 and 40 years old Exclusion Criteria: * Claustrophobia or not comfortable in enclosed spaces. * Colorblindness. * Inability to hear verbal instructions. * Cardiovascular disease which, in the opinion of the investigator, would elevate the participant's risk of adverse effects to WRAP exposure. This includes a history of stroke. * Diabetes requiring the use of insulin. * Pregnancy (A pregnancy test will be provided to you). * Current asthma (an asthma attack within the past five years). * History of childhood asthma. * Medications which may affect cognition such as beta-blockers and CNS depressants. * Respiratory symptoms in the previous 4 weeks (cough, wheezing, shortness of breath, etc.) which, in the opinion of the investigator, would elevate the participant's risk of adverse effects to WRAP exposure. * Use of sedating cold/allergy medications in the previous week. * Use of marijuana in the previous week. * Consumption of alcohol in the previous 24 hours. * Kidney or liver disease. * Thyroid disease. * High blood pressure. * Cancer. * Parkinson's disease. * Pacemaker. * Hay fever.

What they're measuring

Changes in plasma P-tau 217 concentration from pre-exposure to post-exposure

Timeframe: Immediately before, immediately after each exposure

Trial details

NCT IDNCT07151235

SponsorRutgers, The State University of New Jersey

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-20

View on ClinicalTrials.gov More Healthy Participants trials