The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine (NCT07150624) | Clinical Trial Compass
RecruitingPhase 4
The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine
China96 participantsStarted 2025-08-30
Plain-language summary
A multicenter, open-label, randomized, controlled study. It is proposed to evaluate the treatment plan of receiving 930mg polyene phosphatidylcholine injection one day before the operation, twice a day, and 930mg polyene phosphatidylcholine injection twice a day,combined with 100mg of magnesium isoglycyrrhizinate injection once a day,from the 1st to the 5th day after the operation. Compared with the monotherapy regimen of no liver protection treatment before the operation and receiving magnesium isoglycyrrhizinate injection 100mg once a day from the 1st to the 5th day after the operation.The efficacy and safety of treating postoperative liver function injury in patients undergoing laparoscopic hemihepatectomy for hepatocellular carcinoma were compared.
Who can participate
Age range18 Years – 70 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Diagnosed as HCC through imaging and laboratory tests, and capable of undergoing laparoscopic anatomical resection
✓. Those who plan to undergo right or left hemi-liver resection
✓. During the operation, the Pringle method was used to block the first hepatic portal. Each block lasted for no more than 15 minutes, and the blocking procedure was performed 2 to 4 times.
✓. Age: 18 - 70 years old. Gender: Open to both male and female. Body Mass Index (BMI): 18.5 - 28 kg/m2
✓. Child-Pugh grade A or B, with a score of ≤ 7; ASA grades I to III
✓. Preoperative ICG R15 was less than 10%, and the residual liver volume was more than 40% of the standard liver volume
✓. A single HCC (hepatocellular carcinoma), with a tumor diameter less than 10 cm, without distant metastasis or invasion of the portal vein system
✓. Preoperative ALT was less than 2 times the upper limit of normal
Exclusion criteria
What they're measuring
1
The average change of ALT on the 5th day after the operation