CompletedNot Applicable

Probiotic Nanofiber Floss and Subgingival Pathogen Suppression

Czechia33 participantsStarted 2022-02-01

Plain-language summary

This randomized, double-blind, crossover clinical trial evaluated the effect of a probiotic-containing nanofiber dental floss on subgingival red complex periopathogens and gingival health in periodontally healthy individuals. Thirty male participants underwent two 14-day flossing interventions (probiotic floss and placebo floss), separated by a 14-day washout period. Clinical and microbiological parameters were assessed using standardized indices and multiplex qPCR. This study was conducted prospectively but is being registered retrospectively to ensure transparency and compliance with NIH guidelines.

Who can participate

Age range18 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male adults (≥18 years) of Czech or Slovak nationality * ≥20 own teeth * Good oral hygiene * Maximum Stage 2 periodontitis Exclusion Criteria: * Immunocompromised status * Systemic illness * Antibiotic use within 2 months * Smoking * Probiotic use during study

What they're measuring

Change in Approximal Plaque Index (API)

Timeframe: 14 days of each intervention

Change in Sulcus Bleeding Index (SBI)

Timeframe: 14 days of each intervention

Trial details

NCT IDNCT07149493

SponsorSt. Anne's University Hospital Brno, Czech Republic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06-24

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