The goal of this clinical trial is to learn if metformin can reduce the increase in endometrial thickness caused by tamoxifen in women with estrogen-positive breast cancer taking tamoxifen for more than 1 year. It will also learn about the safety of taking metformin with tamoxifen. The main questions it aims to answer are: 1. Does metformin decrease endometrial thickness in women receiving tamoxifen? 2. What medical problems do participants have when taking metformin with tamoxifen? Researchers will compare tamoxifen plus metformin to tamoxifen plus placebo to see if metformin works to reduce endometrial thickness compared to placebo patients. Participants will: 1. Take metformin daily along with tamoxifen, or take tamoxifen with placebo. 2. Acquire baseline assessment and then visit the clinic at 3 months, 6 months, 9 months and 12 months for checkups and trans abdominal ultrasound test for endometrial thickness, and to be monitored for any side effects or complications.
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Change in endometrial thickness
Timeframe: Baseline, 3 months, 6 months, 9 months, and 12 months from enrollment