Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines (NCT07142369) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines
United States99 participantsStarted 2026-09
Plain-language summary
The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.
Who can participate
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 - 50
* English-speaking
* Clinical evidence of ACL rupture with swelling
* Participant must be undergoing ACL reconstruction surgery
Exclusion Criteria:
* Age \<18 or \>50
* Presentation \>3 weeks after initial injury
* Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
* \> Kellgren-Lawrence grade 2 changes on preoperative x-ray
* History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying synovial fluid withdrawal and PRP injections after an ACL tear — how do these approaches compare to just having standard ACL reconstruction surgery, and which path makes more sense for my specific injury?
2Since this trial is not yet recruiting, how long might it be before I could even enroll, and is waiting for this study a realistic option given where I am in my recovery timeline?
3The trial is measuring collagen type II cytokine levels — can you explain in plain terms what that means for my joint health, and what researchers are hoping to learn from tracking that?
4PRP injections carry their own risks and the trial is listed as Phase NA, meaning it may not follow the typical phase progression where safety and effectiveness are already established — what are the known unknowns I should be aware of before considering this?
5Could participating in this trial affect my eligibility for other ACL treatments down the road, particularly if I eventually need surgery or want to prevent posttraumatic osteoarthritis?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.