Not Yet RecruitingNot Applicable

Life Expectancy-informed Colorectal Cancer Screening

United States15,000 participantsStarted 2026-08-01

Plain-language summary

The purpose of this study is to improve life-expectancy concordant colorectal cancer screening for adults over 75 years through design and testing of a life expectancy notification to clinicians delivered via the electronic health record. This study has three components: 1. The investigators will develop a life expectancy prediction model using patient data from the Cleveland Clinic electronic health record (EHR) and test it against two existing life expectancy prediction models to determine which should be used in clinical care. This is an observational cohort study. 2. Concurrently with the development and testing of the life expectancy prediction model, the investigators will conduct interviews with clinicians to generate knowledge regarding the optimal way to integrate life expectancy information into decision making about colorectal cancer screening in patients over 75 years. This is a qualitative study. 3. The investigators will then conduct a cluster randomized trial of a clinical decision support-delivered life expectancy notification on life expectancy-congruent colorectal cancer screening orders by primary care clinicians.

Who can participate

Age range

76 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aim 1a: Patients must meet all the inclusion criteria listed below to be included: * \> 75 years of age * Resident of Ohio * Had at least one Internal Medicine or Family Medicine visit at Cleveland Clinic Health System between January 1, 2007, and September 1, 2022. Aim 1b: Clinicians must meet all the inclusion criteria listed below to be included: * Internal Medicine or Family Medicine clinician (MD, DO, or APP) practicing at Cleveland Clinic Health System in Northeast Ohio * Saw ≥10 study-eligible patients, defined as patients aged \>75 years who were due or overdue for colorectal cancer screening, between 2024-2025 * With a colonoscopy ordering rate for patients \>75 years in either the top quarter of the distribution of all eligible clinicians or bottom quarter of all eligible clinicians Aim 2: Clinics must meet all the inclusion criteria listed below to be included: • Internal Medicine or Family Medicine clinical site included in the Cleveland Clinic Health System in Northeast Ohio or Florida Clinicians must meet all the inclusion criteria listed below to be included: * Currently practicing in Internal or Family Medicine as an attending clinician * Saw ≥10 study-eligible patients, defined as patients aged \>75 years who were due or overdue for colorectal cancer screening, between 2024-2025 Patients must meet all the inclusion criteria listed below to be included: * \>75 years of age * Have not received a colonoscopy in the prior 10 …

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Life-expectancy congruent colonoscopy ordering at the clinic level

Timeframe: 7 days

Trial details

NCT IDNCT07141901

SponsorKathryn Martinez

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-01-01

Contact for this trial

Kathryn Martinez, PhD

216 636-0673 MARTINK12@ccf.org

View on ClinicalTrials.gov More Colorectal Cancer Control and Prevention trials