By InvitationNot Applicable

Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO

United States10 participantsStarted 2026-01-27

Plain-language summary

The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by Electrical Impedance Tomography (EIT) and esophageal pressure measurements on lung mechanics and V/Q optimization.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults (≥18 years) undergoing mechanical ventilation during peripheral VA ECMO support for cardiogenic shock, cardiac arrest, or refractory heart failure. * On ECMO support for at least 6 hours * Swan-Ganz catheter required as standard clinical care * Clinically stable in the estimation of the study investigator Exclusion Criteria: * Contraindications to EIT (e.g., presence of pacemaker or IMPELLA device for electrical interference) * Patients without pulmonary flow (non-pulsatile pulmonary prSessure) * Patients with known pulmonary embolism * Imminent withdrawal of life support

What they're measuring

V/Q match

Timeframe: 1 hour

Trial details

NCT IDNCT07141524

SponsorBeth Israel Deaconess Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-31

View on ClinicalTrials.gov More VA-ECMO trials