Hyperbaric Oxygen Therapy to Improve Autologous Fat Graft Intake in Irradiated Breast

Inclusion Criteria: * Adult (18 y.o. or more) female patients considered for lipofilling following breast reconstruction in an oncological setting which received radiation therapy on the affected breast. * Ability to provide informed consent, documented by signature Exclusion Criteria: * Pregnancy or breastfeeding * Unability to provide informed consent * Previous enrolment into the current investigation Contra-indication to HBOT : * Anamnestically reported spontaneous pneumothorax * Status post-thoracotomy * Significant intra-pulmonary lesions (including emphysematous bullae) * Respiratory function disorders (both obstructive and restrictive syndromes) * Pregnancy * Major psychiatric disorders * Uncontrollable claustrophobic reaction * Seizures, even if treated and asymptomatic for some time * Status post-severe traumatic brain injury with neurological deficits and seizures * Decompensated heart failure * Recent myocardial infarction (\<6 months) or with persistent hemodynamic sequelae * Spastic coronary angina * Cardiac arrhythmias, atrioventricular block, Wolff-Parkinson-White syndrome, sinus node dysfunction, Lown-Ganong-Levine syndrome * Cardiac pacemakers with unknown pressure resistance * Severe bradycardia * Sinus ostium displacement (acute or chronic) * Displacement of the auditory canal entrance (acute or chronic) * Status post-tympanoplasty type I-III \<3 months * Acute febrile state * Optic neuritis * Unstabilized hyperthyroidism Contra-indication to MRI : …