Active — Not RecruitingNot Applicable

The Impact Opioid Free Anesthesia on Postoperative Pain Intensity and Stress Response After Open Gynecology Surgery

Bosnia and Herzegovina80 participantsStarted 2025-07-17

Plain-language summary

This studi compared impact of multimodal balancing anesthesia vs opioid free anesthesia on postoperative pain intensity and stress response after open gynecology surgery. Hypothesis was: opioid free anesthesia reduces postoperative pain intensity and stress response in terms of the value for pain in VAS (Visual Analog Scala) and for stress response in value of cortisol, prolactin and IL-6, CRP and improves postoperative patients subjective well-being and surgical outcome.

Who can participate

Age range18 Years – 65 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria:• participants with ASA physical status class I-II * aged between 18 years and 65 years * participants scheduled for elective open gynecology surgery non cancer Exclusion Criteria: body mass index above 30 kg/m2, diabetes mellitus, emergence surgery, cardiopulmonary disease, neuromusular disease, renal disease, vaginal hysterectomy, hepatic or endocrine disease, pregnancy, mental disease, allergy to any study drugs, alcoholic or drug abuse, ASA III and IV, patient's refusal to participate in the study, duration of surgery below 30min and over 90min.

What they're measuring

Postoperative stress respons

Timeframe: blood samples were taken at 06:00am on the day of surgeon(basal value), 6 hours post-surgeon, at 06:00 am on the first postoperative day

Trial details

NCT IDNCT07138053

SponsorCantonal Hospital Zenica

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-01

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