Optimizing Liver MRI Using Breath-Holding With and Without Oxygen (NCT07135401) | Clinical Trial Compass
RecruitingNot Applicable
Optimizing Liver MRI Using Breath-Holding With and Without Oxygen
United States10 participantsStarted 2025-12-01
Plain-language summary
The goal of this interventional study (clinical trial) is to learn if different breath-holding techniques, with and without extra oxygen, can improve the quality of abdominal Magnetic Resonance Imaging (MRI) images in healthy adults, ages 18-75.
The main questions it aims to answer are:
* Does breath-holding at end-expiration improve image quality in abdominal MRI scans?
* Does adding oxygen while breath-holding further reduce motion artifacts in abdominal MRI scans?
Researchers will compare breath-holding with and without oxygen to see if using oxygen improves image quality during MRI scans.
Participants will:
* Be pre-screened for MRI safety and trained on breath-hold procedures
* Have one non-contrast abdominal MRI scan at the University of California San Francisco (UCSF) China Basin Imaging Center
* Use two different breath-holding techniques during the scan, with and without oxygen
* Complete one study visit lasting about 45 minutes to 1 hour
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion Criteria:
* Subject must be within 18-75 years of age;
* Subject must be able to hear and understand instructions without assistive devices;
* Subject must provide written informed consent;
* Subject has the necessary mental capacity to understand instructions, and is able to comply with protocol requirements;
* Subject is able to remain still for duration of imaging procedure (approximately 30-45 minutes)
Exclusion Criteria:
* Subjects with a weight greater than 499 lbs;
* Subjects that have metallic/conductive or electrically/magnetically active implants without Magnetic Resonance (MR) Safe or Magnetic Resonance (MR) Conditional labeling, with the exception of dental devices/fillings, surgical clips, and surgical staples determined to be safe for MRI scanning by a physician investigator;
* Subjects that have implants with MR Unsafe labeling;
* Subjects that have implants labeled as MR Conditional by the manufacturer for which the allowable conditions are not expected to be achieved by the MR environment or scan protocol;
* Subjects who have a contraindication to MRI per the screening policy of the participating site;
* Subjects with any respiratory or cardiovascular condition that could compromise safe breath holding;
* Subjects who are female and pregnant
What they're measuring
1
Liver MRI Image Quality (Motion Artifacts)
Timeframe: During the single MRI session (approximately 1 hour)