Multimodal Imaging Evaluation of Vulnerability of Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWS

Inclusion Criteria: * At least 18 years old; * Severe stenosis of intracranial arteries (stenosis degree: 70% \~ 99%, traditional angiography is required to confirm the degree of stenosis according to the criteria of Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) study); * Carry out cerebral angiography and OCT within one week after HR-VWI examination; * The patient or the legal representative of the patient is able and willing to sign an informed consent form. Exclusion Criteria: * Non-atherosclerotic intracranial and extracranial artery stenosis, such as dissection, smoke disease, etc.; * There are contraindications to MRI, such as claustrophobia, metal implants, etc.; Renal insufficiency, elevated serum creatinine (more than twice the upper limit of normal); * Patients with severe cardiopulmonary diseases were considered unsuitable for this study; * Allergy to iodine or gadolinium contrast agent; * Participants who were unable to complete the study due to mental illness, cognitive or emotional disorder.