This retrospective, single-centre observational study evaluates perioperative determinants and clinical outcomes of postoperative acute kidney injury (AKI) in patients undergoing pulmonary endarterectomy (PEA) between 2018 and 2020. AKI is classified according to KDIGO 2012 criteria using both serum creatinine changes and urine output over 48 hours. Preoperative, intraoperative and postoperative variables are assessed using multivariable logistic regression. Intraoperative time variables - including extracorporeal circulation (ECC) duration, deep hypothermic circulatory arrest (DHCA) duration and aortic cross-clamp time - are entered simultaneously to identify which component independently captures renal risk. The study also evaluates a parsimonious multivariable risk-stratification model based on routinely available perioperative data. Secondary outcomes include 30-day mortality, intensive care unit stay, hospital length of stay and renal replacement therapy requirement. Findings from this study may provide insights into perioperative risk stratification and renal monitoring strategies in patients undergoing pulmonary endarterectomy.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18-85 years
* Underwent pulmonary endarterectomy between 2018 and 2020
Exclusion Criteria:
* Age below 18 years
* Pregnant women
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial has already been completed and was studying what causes acute kidney injury after pulmonary endarterectomy surgery, has my doctor seen the results, and do those findings change how they would manage my kidneys during or after my own surgery?
2This trial specifically looked at hypothermic circulatory arrest time as a potential factor in kidney injury — can my doctor explain how long they typically pause circulation during pulmonary endarterectomy and what steps they take to protect my kidneys during that period?
3Because this was an observational study measuring how often AKI happens and what perioperative factors are linked to it, rather than a treatment trial, what does my doctor know about the actual rate of kidney injury after this surgery and how serious those cases tend to be?
4Given that this study focused on pulmonary thromboembolism patients undergoing pulmonary endarterectomy, can my doctor help me understand whether I have any personal risk factors — like existing kidney disease or heart function issues — that might put me at higher risk for this complication?
5Now that this trial is completed, are there any follow-up studies or practice changes at my doctor's center based on what was learned about preventing acute kidney injury after pulmonary endarterectomy?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence and Perioperative Determinants of Postoperative Acute Kidney Injury