By InvitationEarly Phase 1

Study on the Mechanism of Zuoqing San Promoting Postoperative Wound Healing of Anal Fistula by Inhibiting ROS-dependent NETosis

China60 participantsStarted 2025-08-01

Plain-language summary

This study adopted a randomized, double-blind, placebo-controlled clinical trial design to evaluate the efficacy and safety of Zuoqing San fumigation and washing on the wound healing after anal fistula surgery.

Who can participate

Age range18 Years

SexALL

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Exclusion criteria

✕. Inflammatory bowel disease (such as Crohn's disease) related anal fistula;
✕. Complicated with severe dysfunction of heart, liver and kidney (ALT/AST \> 2 times upper limit, Cr \> 1.5 mg/dL);
✕. Pregnant or lactating women;
✕. Those who are known to be allergic to the components of Zuoqing San;

What they're measuring

Wound healing time

Timeframe: From postoperative day 1 until wound healing is achieved (assessed daily during hospitalization and weekly after discharge, up to 8 weeks)

Trial details

NCT IDNCT07128953

SponsorThe Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-02

View on ClinicalTrials.gov More Anal Fistula trials