Metabolic and Epigenetic Impact of FAAH Inhibitors and OEA (NCT07127445) | Clinical Trial Compass
CompletedNot Applicable
Metabolic and Epigenetic Impact of FAAH Inhibitors and OEA
United States92 participantsStarted 2025-08-19
Plain-language summary
The goal of this clinical trial is to learn whether a dietary supplement can affect gene expression and serum protein markers in healthy volunteers. The main questions it aims to answer are:
1. Does the supplement affect gene expression and protein markers as measured in blood?
2. How does daily ingestion of the supplement affect anthropometric measurements, including body mass index, waist circumference, blood pressure, and heart rate?
3. How does daily ingestion of the supplement affect subjective health parameters?
4. Is ingesting the supplement daily safe, as measured by laboratory tests and adverse events?
The supplement is made with oleoylethanolamide (OEA), ginger extract, and lavender essential oil.
Participants will:
* Take one supplement capsule in the morning and one in the evening every day for 12 weeks
* Attend three study visits in which they provide blood and urine samples, and undergo anthropometric measurements
* Complete surveys and subjective health assessments
Who can participate
Age range
18 Years – 64 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults ages 18-64 years old
* BMI 25-30 inclusive (self-reported for screening, confirmed at first study visit)
* For purposes of blood collection and other in-person procedures:
o Reside within driving distance of the study center or be willing to travel to the study center
* Willing and able to undergo three blood draws over 12 weeks
* Willing to wash out of all internally-consumed essential oils or botanical products for at least 2 weeks prior to starting the study, and willing to maintain the washout for the duration of the study (14 weeks).
* Willing and able to consume study product twice daily for about 12 weeks
* Willing to track consumption of study product
* Willing to keep diet, exercise, sleep habits, and current non-study supplement use the same throughout the study
* Willing to limit alcohol consumption to "social drinking" (typically no more than 3 drinks per day and 7 per week) during the study
* History of alcohol consumption limited to "social drinking" (typically no more than 3 drinks per day and 7 per week)
* Willing to avoid recreational drugs and smoking/vaping for the duration of the study (approximately 12 weeks)
* No metabolic disease (BMI\>30, diagnosis and treatment of hypertension, diabetes, or dyslipidemia)
* No major diseases under treatment by doctor (Medical Reviewer's discretion)
* No pregnancy within the last 60 days or currently breastfeeding (females)
* No allergy to olive oil, lavender essential oil, ginger oleore…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.