RecruitingPhase 4

The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality

United States132 participantsStarted 2025-08-01

Plain-language summary

The goal of this clinical trial is to learn how GLP-1 and GIP agonists effect bowel preparation in patients scheduled for colonoscopies. The main questions it aims to answer are: * Does GLP-1 and GIP agonist increase the rate of inadequate bowel preparation? * Does the quality of bowel preparation differ in patients who hold vs. those who continue a single dose of their GLP-1 or GIP agonist medication? * Are there any differences in the rates of complications gastric aspiration in patients who hold vs. continue a single dose of their GLP-1 or GIP agonist medication?

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

✕. Cirrhosis
✕. Parkinson's disease
✕. Dementia
✕. Tricyclic antidepressant use
✕. Opioid use
✕. Gastroparesis\* or suspected gastric outlet obstruction on pre-procedure imaging (\*defined based on a documented 4-hour solid phase gastric emptying study or prior history of retained gastric contents during upper endoscopy)
✕. Previous colorectal surgery
✕. Prior history of inadequate bowel preparation

What they're measuring

Rate of inadequate bowel preparation

Timeframe: During Surgery

Trial details

NCT IDNCT07127354

SponsorThe Cleveland Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08

View on ClinicalTrials.gov More GLP - 1 trials