RecruitingNot Applicable

Placental Characteristics Within Monochorionic Twin Pregnancies

United Kingdom65 participantsStarted 2024-12-12

Plain-language summary

This prospective study aims to collate a comprehensive database of all main monochorionic twin groups to enable comparisons to be made within each twin group and additionally between each group with regards to several placental characteristics, whilst understanding their impact on several fetal outcomes. This study aims to provide new insights in to how the placental architecture influences pregnancy care within the UK pregnancy cohort. Results of this study may impact how clinicians conduct antenatal surveillance for these anatomical placental factors. Patients of both uncomplicated and complication monochorionic twin groups will be consented at a single site and recruited during the antenatal period. Following delivery the placenta will then be analysed macroscopically and assessed for several anatomical features. This will be compared with the antenatal complications and perinatal outcomes for the respective twin.

Who can participate

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: • All consecutive placentas of monochorionic twin pregnancies whereby the placenta is transferred to the pathology department for analysis. Exclusion Criteria: * Singleton, dichorionic and higher order pregnancies (e.g. triplet). * Fetus with known major congenital anomalies or aneuploidy

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

What is the impact of intertwin vascular anastomoses on fetal complications and perinatal outcome

Timeframe: Throughout the study period (approximately 2 years)

What is the impact of abnormal cord insertion on fetal complications and perinatal perinatal outcome

Timeframe: Throughout the study period (approximately 2 years

What is the impact of twin placental sharing on fetal complications and perinatal outcome

Timeframe: Throughout the study period (approximately 2 years)

Trial details

NCT IDNCT07124312

SponsorBirmingham Women's NHS Foundation Trust

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2027-01-01

Contact for this trial

Jack Hamer, MBChB

0121 472 1377 jack.hamer1@nhs.net

View on ClinicalTrials.gov More Placenta trials

Plain-language summary

Who can participate

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

What is the impact of intertwin vascular anastomoses on fetal complications and perinatal outcome

Timeframe: Throughout the study period (approximately 2 years)

What is the impact of abnormal cord insertion on fetal complications and perinatal perinatal outcome

Timeframe: Throughout the study period (approximately 2 years

What is the impact of twin placental sharing on fetal complications and perinatal outcome

Timeframe: Throughout the study period (approximately 2 years)