CompletedNot Applicable

The Effect of Platelet-Rich Plasma on Wound Healing After Gingivectomy

Turkey (Türkiye)38 participantsStarted 2021-06-02

Plain-language summary

The aim of the study is to evaluate the effects of using droplet-form platelet-rich plasma (PRP), known to have positive effects during the intermediate healing process, on wound healing in areas left for secondary healing after gingivectomy. After the gingivectomy procedure, patients will be divided into four groups, each consisting of 10 individuals: Group 1 (Control Group): This group will follow the standard post-gingivectomy protocol without any agent applied to the surgical site. Group 2 (Placebo Group): In this group, the standard protocol will be followed, and physiological saline will be applied to the surgical site in 3-4 drops, four times a day, for 14 days. Groups 3 and 4 (Study Groups): These groups will follow the standard protocol, with PRP prepared using different kits applied to the surgical site in 3-4 drops, four times a day, for 14 days. All patients in the groups will be evaluated on the 3rd, 7th, 14th, and 30th days after the gingivectomy procedure. Postoperative pain will be assessed using the Visual Analog Scale (VAS), while wound healing will be evaluated using the Healing Index (Landry et al.) based on photographs of the region. Before taking standardized photographs, the surgical area will be stained with two-tone dye.

Who can participate

Age range

18 Years – 55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Systemically healthy individuals * Patients with inflammatory gingival overgrowth * Patients who have not received periodontal treatment in the area to be treated within the last year * Non-smokers * Patients with intact periodontal structures Exclusion Criteria: * Pregnancy or lactation * Age under 18 or over 55 * Smoking * Presence of systemic diseases * Patients who have received periodontal treatment in the area to be treated within the last year * Use of medications causing gingival overgrowth

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The amount of wound healing

Timeframe: On the 3rd, 7th, 14th, and 30th days following the gingivectomy procedure

Trial details

NCT IDNCT07124143

SponsorDuygu Kilic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-02

View on ClinicalTrials.gov More Gingival Overgrowth trials