CompletedNot Applicable

Pumpkin Seeds or Oil Lower Serum Triglyceride Levels in Individuals With Hyperlipidaemia

Turkey (Türkiye)159 participantsStarted 2022-06-01

Plain-language summary

Aim of the Study: This randomized controlled experimental study aimed to evaluate the effects of cholesterol-restricted diets enriched with pumpkin seeds and pumpkin seed oil on cardiovascular risk factors-specifically serum lipid profile (total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides), blood pressure, and anthropometric measurements (body weight, body mass index, body fat percentage, and fat mass)-in individuals with hyperlipidemia. Research Questions: Does the nutritional intervention lead to a reduction in serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels, as well as an increase in high-density lipoprotein cholesterol (HDL-C) levels across all study groups? Do the groups receiving diets enriched with pumpkin seeds or pumpkin seed oil show greater improvements in lipid profile (TC, LDL-C, TG) and a more pronounced increase in HDL-C compared to the control group? Does the nutritional intervention result in reductions in body weight, BMI, body fat percentage, and fat mass in all study groups?

Who can participate

Age range

19 Years – 64 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria Participants must meet all of the following criteria: * Aged between 19 and 64 years * Body mass index (BMI) between 25.0 and 30.0 kg/m² * Triglyceride (TG) level \> 200 mg/dL * Low-density lipoprotein cholesterol (LDL-C) between 130 and 190 mg/dL * Fasting blood glucose \< 110 mg/dL * Blood pressure below 140/90 mmHg Exclusion Criteria * Individuals will be excluded if they meet any of the following criteria: * Diagnosis of any systemic disease, including: * Diabetes mellitus * Hypertension * Cancer * Metabolic syndrome * Chronic kidney disease * Use of any medication that affects blood lipid, glucose, and pressure levels * Presence of food allergies (e.g., to pumpkin seeds or oil) * Current or recent nutritional treatment or dietary therapy * Pregnancy or breastfeeding * Diagnosed psychiatric disorders * Known congenital metabolic disorders

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Serum Total Cholesterol (mg/dL) from Baseline to Day 28

Timeframe: Baseline and Day 28

Change in Serum LDL-Cholesterol (mg/dL) from Baseline to Day 28

Timeframe: Baseline and Day 28

Change in Serum HDL-Cholesterol (mg/dL) from Baseline to Day 28

Timeframe: Baseline and Day 28

Change in Serum Triglycerides (mg/dL) from Baseline to Day 28

Timeframe: Baseline and Day 28

Trial details

NCT IDNCT07123844

SponsorKastamonu University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-09-30

View on ClinicalTrials.gov More Hyperlipidemia trials

Plain-language summary

Who can participate

Age range

19 Years – 64 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Serum Total Cholesterol (mg/dL) from Baseline to Day 28

Timeframe: Baseline and Day 28

Change in Serum LDL-Cholesterol (mg/dL) from Baseline to Day 28

Timeframe: Baseline and Day 28

Change in Serum HDL-Cholesterol (mg/dL) from Baseline to Day 28

Timeframe: Baseline and Day 28

Change in Serum Triglycerides (mg/dL) from Baseline to Day 28

Timeframe: Baseline and Day 28