Neural Contributions to Exercise-Induced Hypoalgesia With Blood Flow Restriction (NCT07122011) | Clinical Trial Compass
CompletedNot Applicable
Neural Contributions to Exercise-Induced Hypoalgesia With Blood Flow Restriction
Argentina20 participantsStarted 2025-08-04
Plain-language summary
This experimental study explores the neurophysiological mechanisms associated with pain modulation following a single session of low-intensity resistance exercise combined with BFR in healthy young adults. The study evaluates changes in sensory thresholds before and after the intervention using validated quantitative sensory testing (QST) methods. These include pressure pain thresholds, conditioned pain modulation, thermal thresholds, and temporal summation. The findings may contribute to a better understanding of the role of the nervous system in exercise-induced hypoalgesia, particularly in response to BFR protocols, with implications for future research in pain and rehabilitation.
Who can participate
Age range
18 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Asymptomatic at the time of evaluation.
* Able to provide written informed consent.
* Available to attend a single evaluation and intervention session at the research center.
Exclusion Criteria:
* Bilateral knee symptoms or suspected patellar tendinopathy.
* Increased symptoms with dynamic loading.
* Neurological disorders.
* Inflammatory rheumatic diseases.
* Cardiac diseases.
* Any surgery within the last 3 months.
* Pregnancy.
* Alcohol consumption on the day of participation.
* Hypertension (systolic blood pressure ≥140 mmHg).
* History of deep vein thrombosis.
* History of endothelial dysfunction.
* Peripheral vascular disease.
* Diabetes.
* Active infection.
* Spinal or referred pain.
* Previous experience with blood flow restriction (BFR) training.
* Overweight or obesity.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
CPM
Timeframe: Baseline (before intervention) and immediately after the intervention session.
2
PPT
Timeframe: At baseline and immediately after the intervention session.