Lifestyle Intervention and Its Effects on Inflammatory Cytokines and Oxidative Stress Markers in Diabetic Chronic Kidney Disease Patients: A Randomized Controlled Trial

Inclusion Criteria: Participants must meet all of the following: * Diagnosed with Type 2 Diabetes Mellitus (T2DM) * Diagnosed with moderate chronic kidney disease (CKD Stage 3 or 4), with eGFR 25-60 mL/min/1.73 m² * Age between 36 and 58 years * BMI between 30-35 kg/m² (classified as obese) * Sedentary lifestyle, defined as \<30 minutes of physical activity per week over the past 6 months * Stable medication regimen for at least 3 months * Willing and able to provide informed consent Exclusion Criteria: * Participants will be excluded if they: * Use anti-inflammatory medications regularly * Have congestive heart failure (CHF) or coronary artery disease (CAD) * Have moderate to severe valvular heart disease * Have active liver disease (ALT \> 3× upper normal limit) * Have orthopedic limitations preventing exercise participation * Are currently pregnant or lactating * Have received a kidney transplant * Have respiratory failure or chronic pulmonary disease * Are smokers (current) Have participated in a lifestyle intervention trial within the last 6 months