Papilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Treating Isolated Bone Defects Between Teeth

Inclusion Criteria: * stage II or III periodontitis, according to WWP 2017 classification of periodontal diseases in need of periodontal regenerative treatment for isolated intrabony defects * single-rooted teeth/multi-rooted teeth without furcation involvement Exclusion Criteria: * uncontrolled or poorly controlled diabetes, * unstable or life-threatening conditions, or requiring antibiotic prophylaxis, * History of use of medications since last 6 months (immunosuppressants and antibiotics), * Subjects allergic to medications, * Pregnant or lactating women, Smokers/users of other tobacco products, * Subjects showing unacceptable oral hygiene maintenance after initial phase I therapy and * multiple interconnected vertical defects.