Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain (NCT07116304) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain
30 participantsStarted 2025-08-01
Plain-language summary
Propofol is the most popular IV anaesthetic agent used for induction, however one of its known side effects is causing pain on injection, the gold standard method in preventing this pain is using lidocaine prior to injecting propofol. multiple drugs have been investigated to reduce the aforementioned pain, however there has been no study comparing lidocaine to parecoxib, an NSAID.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients, ≥18 years
* ASA grading I-II
* Patients undergoing elective surgical procedures across all surgical specialties.
* Can speak Arabic or English
Exclusion Criteria:
* Difficulty in communicating.
* Liver Cirrhosis patients
* Renal failure or creatinine clearance (CrCl) ≤ 10umol/L,
* Known Lidocaine, parecoxib and/or propofol allergy.
* patients who are not using propofol for an induction.
* Any known contraindication to propofol, parecoxib or lidocaine. (this will include renal failure or cirrhosis of the liver as noted above)
* Patients refusing to be involved in the study.
* ASA(American society of anaesthesia) grading 3-6.
* Any patient that IV access cannot be established in the dorsum of the hand.
* Pregnant women.
* Patients with chronic pain disorders.
* Patients who received any form of analgesia within the last hour.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
incidence of pain on injecting propofol after receiving the treatment assigned.
Timeframe: immediately after injection of 50 mg of propofol.