Active — Not RecruitingNot Applicable

Effect of Different Irrigation Protocols on Postoperative Endodontic Pain and Inflammation

Egypt75 participantsStarted 2023-08-20

Plain-language summary

This study aims to improve the postoperative endodontic outcome by assessing the effect of different irrigants on postoperative endodontic pain and their anti-inflammatory effects.

Who can participate

Age range18 Years – 60 Years

SexALL

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Inclusion criteria

✓. Patients presenting with a single rooted tooth (maxillary anteriors and mandibular premolars) with closed apex and a single patent canal type I in Vertucci's classification (Vertucci et al., 1974)
✓. Having a necrotic pulp and asymptomatic apical periodontitis (periapical lesion).
✓. Periapical lesions of endodontic origin with a diameter ranging from 2 to 5mm, having a periapical index score of 4 or 5 (Orstavik, Kerekes and Eriksen, 1986)

What they're measuring

Postoperative pain assessment using Numerical Rating Scale NRS

Timeframe: Postoperative pain was assessed after 6, 12, 24, 48 hours and 7 days after the first visit using a numerical rating scale NRS

MMP-9 levels in periapical tissues using periapical fluid samples using a commercially available ELISA kit

Timeframe: After the final rinse (S1) and after one week (S2).

Trial details

NCT IDNCT07116252

SponsorSuez Canal University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-09

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