Daily Amino Acid Supplementation for People With Parkinson's Disease (NCT07115563) | Clinical Trial Compass
RecruitingNot Applicable
Daily Amino Acid Supplementation for People With Parkinson's Disease
United States30 participantsStarted 2025-10-31
Plain-language summary
The goal of this clinical trial is to learn if a tailored amino acid supplement works to help adults living with Parkinson's disease to improve nutrition, metabolic function, body composition, and physical and mental function. The main questions it aims to answer are:
Does the tailored amino acid supplement increase essential amino acids (nutritional status)?
Does the tailored amino acid supplement increase an antioxidant (complex amino acid) and decrease an amino acid associated with oxidative stress?
Does the tailored amino acid supplement improve physical and mental health compared to a placebo supplement?
Researchers will compare the tailored amino acid supplement to a placebo (a look-alike substance that contains no active ingredients) to see if the tailored amino acid supplements work to support health for people with Parkinson's disease.
Participants will:
Take the tailored amino acid supplement or a placebo every day for 6 months, visit the lab at baseline, after 3 months, and after 6 months for fasting blood draws, body composition assessment, and physical and mental health testing and keep a diary of their food intake and supplement intake.
Who can participate
Age range
50 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusionary Criteria:
* Male and Females.
* 50-80 Years.
* Previous diagnosis of idiopathic Parkinson's Disease by patient report.
* Use of dopamine replacement medication (e.g. levodopa) for at least 2 years.
* On a stable dose of dopamine replacement medication for at least 3 months with no plans for change in the next two months.
Exclusionary criteria
* Apparent cognitive impairment as determined by phone screening (Telephone Interview for Cognitive Status \<29).
* Diagnosis of Parkinsonism or atypical Parkinson's Disease.
* Prescription of Dopamine antagonist.
* Any unstable medical condition.
* Use of Deep Brain Stimulation.
* Gastric or Bowel resection surgery.
* Contraindications to blood draw.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is listed as Phase NA, which can mean it's more of a nutritional or observational study rather than a drug trial — can you help me understand what that means for how much is already known about the safety and benefit of daily amino acid supplementation for Parkinson's disease?
2The trial is measuring levels of specific amino acids like lysine, tryptophan, and glutathione, as well as oxidative stress — given my current Parkinson's symptoms and medication regimen, could any of these amino acids interact with my existing treatments, especially levodopa, which is known to compete with certain amino acids for absorption?
3Since this study is actively recruiting right now, what would my day-to-day involvement actually look like — how often would I need to come in for testing, and would that realistically fit into my life and care schedule?
4The trial focuses on amino acid bioavailability and oxidative stress as outcomes rather than direct Parkinson's symptom improvement — does that mean the goal is more about understanding what's happening in the body than proving a treatment benefit, and what would that mean for me personally if I enrolled?
5Before considering this trial, are there established standard-of-care options or other studies you'd recommend I explore first, given that this appears to be an early-stage investigation into nutritional supplementation rather than a proven therapy?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.