Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets

Inclusion Criteria for COPD subjects * Male or female sex * Age ≥40 years and ≤75 years at the time of signing the consent form * Medical history or clinical diagnosis of COPD * Significant smoking history, defined as: * Cumulative smoking history of at least 20 pack years * Permitted to currently use, or have history of use of, e-cigarettes/vapes * COPD spirometry criteria: * Post bronchodilator FEV1 of \<80% and ≥50% predicted for age and height (equivalent to GOLD criteria stage 2 for 'Moderate' severity COPD9) * Post-bronchodilator FEV1/FVC ratio \<0.7 * β-agonist reversibility: an improvement of less than 12% predicted FEV1 and less than 200mL after 200 micrograms of salbutamol or equivalent short acting beta-2 agonist bronchodilator. * History of acute exacerbations of COPD as defined by the participant answering "yes" to the question: "do your COPD symptoms get noticeably worse when you catch a cold?" * Clinically stable with no COPD exacerbations within 8 weeks prior to enrolment * Permitted to take short and long-acting bronchodilators including beta agonists and muscarinic antagonist inhalers * Co-morbidity criteria: * Permitted to have a past medical history of asthma, allergic rhinitis and seasonal rhinitis, but not currently active within 8 weeks prior to enrolment * Absence of current or previous history of significant respiratory disease, other than COPD, asthma and allergic rhinitis * Permitted to have a positive skin test for atopy Inclusio…