RecruitingNot Applicable

Surface Electrical Myography, Oxygen Consumption, Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit

Netherlands60 participantsStarted 2025-07-08

Plain-language summary

The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing Trial. The main question aims to answer whether the sEMG signal derived from the SERA device, effort parameters and oxygen consumption have an association with weaning failure. Participants will be measured while performing a spontaneous breathing trial.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * 18 years of age or older * Esophageal catheter in situ (standard of care) * Eligible for an SBT in the near future according to the LUMC SBT protocol currently valid Exclusion Criteria: * Severe cardiac failure NYHA class IV without mechanical support (LVAD or Impella) * COPD Gold IV * Pregnancy * Patients with ECMO

What they're measuring

Extubation failure

Timeframe: 48 hours after extubation

sEMG differences during SBT

Timeframe: 10 minutes before switch from support to no support ventilation, the whole duration of the SBT, and the 10 minutes after the SBT when there is again support.

Trial details

NCT IDNCT07109570

SponsorLeiden University Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-12-31

Contact for this trial

Abraham Schoe, MD, PhD

+31715265018 a.schoe@lumc.nl

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