TerminatedNot Applicable

The Effects of Vitamin C on Acute-Exercise in Postmenopausal Females

Stopped: Insufficient funds and study personal to complete the trial when the primary grant holder and coordinator resigned from UVA.

United States1 participantsStarted 2025-09-01

Plain-language summary

This study is looking at whether vitamin C can help improve oxidative stress and blood vessel health in females after menopause. We will see if taking different amounts of vitamin C for a few days changes how the body handles stress from exercise. This could lead to safer ways to protect females from heart disease without using hormone therapy.

Who can participate

Age range

45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Post-menopausal (for females; defined as no menstrual cycle for 1-year) * Sedentary (\<150min of moderate-intensity exercise per week or not engaged in a regular exercise program) * Non-smoking * Weight stable (+/-3 kg over the past 3 months) Exclusion Criteria: * Overt CVD * Any condition or medication contraindicating safe exercise * Hormone replacement therapy (last 3-months) * Use of vasoactive medications (e.g., calcium channel blockers, statins, ACE inhibitors, ARBs, nitrates, alpha-/beta-blockers, diuretics), diabetes, or unstable medication regimens * Diabetes * Oral antibiotic use within previous four weeks * Oral disease or poor oral health as determined by the Oral Health Questionnaire * Using an antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use * Cancer diagnosis

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Flow-Mediated Dilation (FMD%) - Brachial Artery Endothelial Function

Timeframe: 5x: Baseline/un-supplemented; after 3-days of 200mg of vitamin C supplementation; after 3-days of 500mg of vitamin C supplementation; after 3-days of 1000mg of vitamin C supplementation; after 3-days of 0mg of vitamin C/placebo supplementation

Basal ROS Concentrations - plasma 8-Isoprostane (8-iso) and malondialdehyde (MDA)

Timeframe: baseline and after 0mg/placebo, 200mg, 500mg, and 1000mg dose of vitamin C for 3-days each

Resting ROS/NO Balance - plasma N-oxides (nitrite and nitrate)

Timeframe: Baseline and after 3-days of placebo, 200mg, 500mg, and 1000mg doses of vitamin C

Exercise-Induced ROS (plasma 8-Isoprostane (8-iso) and malondialdehyde (MDA)) and NO (plasma nitrate and nitrite)

Timeframe: 16x points: 4 exercise session with blood will be collected immediately before, immediately after, 15-min after, and 30-min after exercise

Trial details

NCT IDNCT07109115

SponsorUniversity of Virginia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-01

View on ClinicalTrials.gov More Females trials