CompletedNot Applicable

Study of the Cognitive and Neurophysiological Effects of the Activ4Brain Program for Older Adults

Portugal72 participantsStarted 2024-01-01

Plain-language summary

This study aims to examine the cognitive, neuronal, and physical effects of the Activ4Brain program in older men and women between 55 and 75 years of age. The program Activ4Brain consists of 24 sessions of aerobic exercise classes (twice a week over 3 months) that include computerized games designed to train cognition. Participants are tested before and after the 3-months intervention. Researchers will study changes in cognitive function, brain and body physiological activity, and inflammation and neuroprotective markers in 3 groups of participants: the Activ4Brain group that engages in the Activ4Brain program, an active control group that engages in aerobic exercise classes and a passive control group that does not engage in any intervention. This study aims to answer the following questions. * Does the program Activ4Brain improve cognition in cognitively healthy older adults? * Does the program Activ4Brain change brain function and body physiology in cognitively healthy older adults?

Who can participate

Age range55 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: • Men and women between 55 and 75 years of age Exclusion Criteria: * Presence of contraindications for physical exercise screened with the Physical Activity Readiness Questionnaire (PAR-Q) * Presence of objective cognitive impairment screened with the Addenbroke's Cognitive Examination - Revised, which also incorporates the Mini Mental State Examination, providing a double score * Presence of high fall risk screened with the Timed Up and Go test (TUG) * Presence of severe neurological or psychiatric conditions

What they're measuring

Change from Baseline in Executive Function - Multitasking test from the CANTAB Research Connect

Timeframe: From one month before the 3-months intervention up to one month after the end of the intervention.

Change from Baseline in Working Memory - Spatial Working Memory (SWM) test from the CANTAB Research Connect

Timeframe: From one month before the 3-months intervention up to one month after the end of the intervention.

Change from Baseline in Episodic Memory - Auditory Verbal Learning Test

Timeframe: From one month before the 3-months intervention up to one month after the end of the intervention.

Change from Baseline in Sustained Attention - Rapid Visual Information Processing test from the CANTAB Research Connect

Timeframe: From one month before the 3-months intervention up to one month after the end of the intervention.

Change from Baseline in Processing Speed - Rapid Visual Information Processing test from the CANTAB Research Connect

Timeframe: From one month before the 3-months intervention up to one month after the end of the intervention.

Change from Baseline in Processing Speed - Multitasking test from the CANTAB Research Connect

Timeframe: From one month before the 3-months intervention up to one month after the end of the intervention.

Trial details

NCT IDNCT07108413

SponsorUniversity of Coimbra

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-30

View on ClinicalTrials.gov More Older People trials