CompletedNot Applicable

Hybrid vs. Conventional Surgery for Type A Aortic Dissection

China140 participantsStarted 2021-01-01

Plain-language summary

This is a prospective, randomized controlled trial designed to compare the clinical efficacy and short-term outcomes of one-stop hybrid surgery versus conventional total arch replacement with frozen elephant trunk (FET) in patients with acute Stanford Type A Aortic Dissection. The study evaluates differences in perioperative metrics, postoperative complications, 30-day survival, aortic remodeling, and quality of life.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-70 years. * Diagnosis of acute TAAD (symptom onset \<72 hours) confirmed by imaging, with dissection involving the aortic arch requiring total arch replacement. * Relative hemodynamic stability, defined as a systolic blood pressure \>90 mmHg without high-dose vasopressor support (norepinephrine \>0.1 µg/kg/min). * Provision of informed consent. Exclusion Criteria: * Age \>70 years. * Stanford type B or non-dissection pathologies. * Life-threatening comorbidities prohibitive of major cardiac surgery (e.g., advanced multiorgan failure from other causes, active malignancy). * Absolute contraindications to surgery. * History of previous ascending aorta or aortic arch surgery. * Inability to provide informed consent.

What they're measuring

Incidence of the Composite Endpoint of 30-day Mortality, Stroke, and Acute Kidney Injury (Stage 2 or 3)

Timeframe: Within 30 days post-procedure

Trial details

NCT IDNCT07107711

SponsorThe First Hospital of Hebei Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-03-30

View on ClinicalTrials.gov More Acute Stanford Type A Aortic Dissection trials