Impact of Non Surgical Periodontal Therapy on Cystatin C Levels (NCT07103421) | Clinical Trial Compass
CompletedNot Applicable
Impact of Non Surgical Periodontal Therapy on Cystatin C Levels
Syria30 participantsStarted 2023-05-12
Plain-language summary
Study the effect of non-surgical periodontal therapy on cystatin C levels in gingival crevicular fluid and serum in both healthy patients and patients with renal impairment. The number of participants is 30 individuals, divided into three groups receiving conservative periodontal treatment (scaling and root planing):Systemically and periodontally healthy patients, Patients with periodontitis without systemic diseases, and Patients with periodontitis and chronic kidney disease. The study also aims to determine the relationship between the severity of periodontal disease and kidney function by measuring cystatin C levels, which is an important biomarker for both conditions. Additionally, it seeks to assess whether non-surgical periodontal therapy can be included in the treatment protocols for kidney patients to improve their quality of life.
Who can participate
Age range
20 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with Stage II (Grade A or B) periodontitis (according to AAP 2017 classification).
* Age range: 20 to 70 years.
* No pathological tooth mobility.
* No furcation involvement caused by periodontal disease.
* No systemic diseases affecting periodontal or renal health.
* No systemic antibiotic use within the previous 3 months.
* No periodontal treatment within the previous 6 months
For Chronic Kidney Disease (CKD) Patients:
* Confirmed CKD diagnosis for at least 3 years (by a consultant nephrologist).
* Receiving conservative management (pre-dialysis).
Exclusion Criteria:
\- Stage III or IV periodontitis.
* Grade C periodontal disease.
* Bone loss in more than 10 sites.
* Pathological tooth mobility (Grade II or III).
* Furcation involvement due to periodontal disease.
* Tooth loss due to periodontal disease.
* Heavy smoking (\>10 cigarettes/day).
* Pregnancy or lactation.
* Patients undergoing dialysis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Cystatin C levels after periodontal therapy
Timeframe: Baseline (before treatment) and 4 weeks after completion of periodontal therapy