RecruitingPhase 2

COMPARISON OF ZINC AND PROBIOTICS ON NEONATES WITH INDIRECT HYPERBILIRUBINEMIA UNDERGOING PHOTOTHERAPY

Pakistan110 participantsStarted 2025-08-07

Plain-language summary

Study will evaluate effects of oral zinc and probiotics supplementation in neonates who have indirect hyperbilirubinemia and are receiving phototherapy. Aim is to compare efficacy of these two drugs in clearing bilirubin and reducing duration of phototherapy. Neonates will be randomly assigned to receive either drug alongside phototherapy.

Who can participate

Age range0 Days – 28 Days

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 1\. Term or Near term neonates 2. Age \<7 days at enrollment 3. Bilirubin levels within phototherapy range according to NICE bilirubin threshold charts 4. No identifiable pathology 5. Tolerating oral feeds 6. Parental or Guardian written informed consent taken. Exclusion Criteria: * 1\. Positive sepsis screen or clinical signs of infection 2. Direct hyperbilirubinemia 3. Gastrointestinal malformations 4. Oral intolerance 5. Requiring mechanical ventilation 6. Congenital anomalies 7. Parental or Guardian refusal to participate in study

What they're measuring

Rate of decline in Bilirubin levels during phototherapy with this adjuvant therapy

Timeframe: From initiation of supplementation with phototherapy to its completion (typically 3-7 days).

Trial details

NCT IDNCT07102836

SponsorQuaid-e-Azam Medical College

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02-07

Contact for this trial

Malik M. Umair Fazal, MBBS, FCPS Paediatrics

+923318682681 umair.malik1622@gmail.com

View on ClinicalTrials.gov More Indirect Hyperbilirubinemia trials