Effects of Intra-articular Hypertonic Dextrose and Hyaluronic Acid on Primary Knee Osteoarthritis.

Inclusion Criteria: * Knee OA diagnosis satisfying the American College of Rheumatology clinical and radiographic criteria, Kellgren-Lawrence grade of II and III determined by Postero-anterior knee radiograph. * Participants will have the ability to undergo 3 months of follow-up * Participants who will agree to avoid non-steroidal anti-inflammatory drugs during the research (acetaminophen will be prescribed for intractable pain) Exclusion Criteria: * Participants who will give a self-reported history of knee surgery, fracture, or infection. * Kellgren-Lawrence grade IV KOA. * Participants on anticoagulants. * Participants who will have previous history of intra-articular knee injection of HA or prolotherapy within 6 months. * Participants who have malignant disease or secondary KOA. * Participants who will have a history of comorbid illness(es) like chronic heart failure, advanced COPD, end-stage renal failure, advanced liver disease and poorly controlled DM.