RecruitingPhase 4

Preoperative Acetazolamide

United States100 participantsStarted 2025-10-30

Plain-language summary

The goal of this randomized study looks at whether giving patients a medicine called acetazolamide (also called Diamox) before they have laparoscopic hysterectomy may decrease postoperative pain. Researchers will compare acetazolamide to a placebo or inactive drug, to see if acetazolamide helps the pain that may occur after surgery from the gas used in the abdomen during the laparoscopic procedure. Patients will be asked to rate their pain before surgery and after surgery through 24 hours.

Who can participate

Age range21 Years – 65 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women * Ages 21-65 * undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without bilateral salpingoophorectomy * undergoing total laparoscopic hysterectomy (TLH) for benign indications with or without cystoscopy Exclusion Criteria: * Allergy to acetazolamide or sulfonamides * Known electrolyte disturbances * Pregnancy * Kidney failure or creatinine \>1.5 * Diuretic or lithium use * Chronic obstructive pulmonary disease (COPD) or other lung disease * Central nervous system disorders * Liver disease * Glaucoma * Preoperative or chronic opioid use * Diagnosis of fibromyalgia * Preoperative shoulder pain * Conversion to laparotomy * Intraoperative bladder or bowel injury * Inability to understand or utilize visual analog scale * Undergoing concurrent reconstructive procedures

What they're measuring

Abdominal/pelvic pain and right subscapular pain rated on a VAS at five perioperative points

Timeframe: From before procedure to 24 hours post procedure

Total analgesic use postoperatively

Timeframe: from end of procedure to 24 hours post procedure

Trial details

NCT IDNCT07101250

SponsorPrisma Health-Upstate

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08-01

Contact for this trial

Patti Parker, BSN

864-455-1510 patti.parker@prismahealth.org