Not Yet RecruitingEarly Phase 1

Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp

30 participantsStarted 2025-08

Plain-language summary

To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on: * Intensity of postoperative pain * levels of MMP -9 in Periapical Fluids.

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age between 18-50 years old.
✓. Males and females.
✓. Healthy patients categorized as I or II according to The American Society of Anesthesiologists.
✓. Single-rooted mandibular premolar teeth, having single root canal:
✓. Patients accepting to participate in the trial.
✓. Patients who can understand pain scale and can sign the informed consent

Exclusion criteria

✕. Medically compromised patients having significant systemic disorders (ASA III or IV).
✕. Pregnant females.
✕. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.
✕. Teeth with multiple canals. 9
✕. Teeth that show association with acute periapical abscess, swelling or fistulous tract.
✕. Teeth with vital pulp.
✕. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam.
✕. Immature teeth.

What they're measuring

Intensity of post-operative pain

Timeframe: 6 hours post-instrumentation

Intensity of post-operative pain

Timeframe: 12 hours post-instrumentation

Intensity of post-operative pain

Timeframe: 24 hours post-instrumentation

Intensity of post-operative pain

Timeframe: 48 hours post-instrumentation

Intensity of post-operative pain

Timeframe: 6 hours post-obturation

Intensity of post-operative pain

Timeframe: 12 hours post-obturation

Intensity of post-operative pain

Timeframe: 24 hours post-obturation

Intensity of post-operative pain

Timeframe: 48 hours post-obturation

Trial details

NCT IDNCT07101029

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07

View on ClinicalTrials.gov More Intracanal Dressing trials

Who can participate

Age range18 Years – 50 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age between 18-50 years old.
✓. Males and females.
✓. Healthy patients categorized as I or II according to The American Society of Anesthesiologists.
✓. Single-rooted mandibular premolar teeth, having single root canal:
✓. Patients accepting to participate in the trial.
✓. Patients who can understand pain scale and can sign the informed consent

Exclusion criteria

✕. Medically compromised patients having significant systemic disorders (ASA III or IV).
✕. Pregnant females.
✕. If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively as it might alter their pain perception.
✕. Teeth with multiple canals. 9
✕. Teeth that show association with acute periapical abscess, swelling or fistulous tract.
✕. Teeth with vital pulp.
✕. Non-restorable teeth or teeth that could not be adequately isolated with a rubber dam.
✕. Immature teeth.

What they're measuring

Intensity of post-operative pain

Timeframe: 6 hours post-instrumentation

Intensity of post-operative pain

Timeframe: 12 hours post-instrumentation

Intensity of post-operative pain

Timeframe: 24 hours post-instrumentation

Intensity of post-operative pain

Timeframe: 48 hours post-instrumentation

Intensity of post-operative pain

Timeframe: 6 hours post-obturation

Intensity of post-operative pain

Timeframe: 12 hours post-obturation

Intensity of post-operative pain

Timeframe: 24 hours post-obturation

Intensity of post-operative pain

Timeframe: 48 hours post-obturation