In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization

Inclusion Criteria: * provide voluntary, written informed consent; * be between 18 and 85 years old; * understand and be willing, able and likely to comply with all study procedures and restrictions; * be wearing a removable mandibular partial denture with sufficient room to accommodate four (4) human enamel specimens (4 mm round) in their partial denture on both sides (two specimens on each side, bilateral partial denture) or one side (4 specimens on one side, unilateral partial denture) * be willing and capable of wearing their removable partial denture 24 hours a day for four (4), one-week treatment periods, maximum total duration four (4) weeks; * be willing to allow study personnel to drill specimen sites in the posterior section of one or both sides of their lower partial denture (teeth and/or buccal flange area below the teeth); and * be in good medical and dental health with no active caries or periodontal disease. * have a salivary flow rate in the range of normal values (unstimulated whole saliva flow rate ≥ 0.2 mL/min; gum base stimulated whole saliva flow rate ≥ 0.8 mL/min). Exclusion Criteria: * currently be pregnant (self-reported), intending to become pregnant during the study period or breast feeding; * currently have any medical condition that could be expected to interfere with the subject's safety during the study period; * currently be taking antibiotics or have taken antibiotics in the two weeks prior to the beginning treatment; * known or suspected in…