Hydrogen-Rich Water and Resting Metabolism in Young Adults (NCT07098221) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Hydrogen-Rich Water and Resting Metabolism in Young Adults
24 participantsStarted 2025-09-01
Plain-language summary
The H2REST trial is a randomized, double-blind, placebo-controlled crossover study investigating the acute effects of a single dose of hydrogen-rich water (HRW) on resting metabolism in healthy young adults. Participants complete two testing sessions-receiving either HRW or placebo in a randomized order-followed by standardized metabolic testing. Primary outcomes include resting energy expenditure, respiratory exchange ratio, and substrate utilization measured via indirect calorimetry. The study aims to assess whether acute HRW intake can modulate metabolic rate and fuel preference at rest, and to explore inter-individual variability in response.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 18-35 years
* BMI between 18.5 and 25.0 kg/m²
* Apparently healthy, with no history of chronic disease
* Non-smoker, not currently using nicotine-containing products
* Able to provide informed consent
* Willing to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each study visit
* Able to comply with study procedures, including fasting and attending all study visits
Exclusion Criteria:
* Diagnosed metabolic, cardiovascular, respiratory, gastrointestinal, or endocrine disorders
* Use of dietary supplements or medications affecting metabolism (within the past 2 weeks)
* Allergy or intolerance to components of the hydrogen or placebo beverages
* Pregnant or lactating
* Shift work or irregular sleep schedule
* Participation in another clinical study within the past 30 days
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Resting Energy Expenditure (REE)
Timeframe: Participants will attend three study visits, with each intervention separated by a 7-day washout period to minimize carry-over effects. During each visit, measurements will be conducted approximately 30-60 minutes post-intervention.