Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Co… (NCT07097220) | Clinical Trial Compass
CompletedNot Applicable
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
China106 participantsStarted 2025-05-16
Plain-language summary
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing hepatectomy.
A retrospective analysis of 80 liver cancer patients was conducted, categorized by analgesic adequacy, pain recovery, and POCD incidence: adequate vs. inadequate analgesia (n=50 vs. n=30), favorable vs. delayed pain recovery (n=36 vs. n=44), and POCD vs. non-POCD (n=42 vs. n=38). Based on these results, a prospective study (April 2024-April 2025) enrolled patients scheduled for elective hepatectomy, assigned to the GA group (n=59) or GEA group (n=47). Primary outcomes included intraoperative analgesic consumption, postoperative VAS pain scores, MoCA cognitive scores, hospital stay length, and adverse event rates.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* Inclusion Criteria:
* Histologically or radiologically confirmed primary liver cancer (HCC or cholangiocarcinoma)
* Scheduled for elective open or laparoscopic radical hepatectomy
* Age 18-75 years
* ASA Physical Status I-III
* Child-Pugh class A or B liver function
* Normal preoperative MoCA score (≥26)
* Willing to participate and provide informed consent
* Exclusion Criteria:
* Severe cardiovascular, pulmonary or renal disease (ASA IV/V)
* Chronic pain disorders or preoperative opioid use (\>3 months)
* Known neurologic/psychiatric conditions (dementia, stroke, epilepsy)
* Concurrent major procedures (e.g., vascular resection)
* Intraoperative conversion to palliative surgery
* Massive intraoperative hemorrhage (\>2000 mL)
* Coagulopathy (INR \>1.5 or platelets \<50×10⁹/L)
* Spinal abnormalities precluding epidural catheterization
* Pregnancy or lactation
* Allergy to local anesthetics or study medications
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.