RecruitingPhase 2/3

Prehospital Early Administration of Ketamine for Status Epilepticus in Epileptic Kids (PEAK-SEEK)

Egypt668 participantsStarted 2025-08-03

Plain-language summary

The goal of this pragmatic, decentralized, pre-consented, event-driven, randomized controlled trial is to investigate the efficacy of add-on ketamine to second-dose midazolam for prehospital treatment of epileptic children with convulsive status epilepticus.

Who can participate

Age range2 Years – 16 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age from 2 to 16 years. * Established diagnosis of epilepsy of at least 1 year duration. * History of at least 1 episode of convulsive status epilepticus in the preceding 12 months. Exclusion Criteria: * Failure to obtain informed consent. * Known allergies or contraindications to ketamine. * Known contraindications to intramuscular injection. * Presence of another family member included in the same trial. * Having subsequent events (only the index event will be included).

What they're measuring

Number of participants with cessation of seizures at the time of hospital arrival

Timeframe: At the time of hospital arrival (up to 1 hour)

Trial details

NCT IDNCT07095842

SponsorSohag University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-30

Contact for this trial

Elsayed Abdelkreem

1114232126 d.elsayedmohammed@med.sohag.edu.eg

View on ClinicalTrials.gov More Convulsive Status EPILEPTICUS trials