RecruitingNot Applicable

Tissue Engineered Cartilage to Repairing Articular Cartilage Defects

China30 participantsStarted 2026-04-20

Plain-language summary

The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. The patients' age ranges from 18 to 65 years old, and gender is not restricted;
✓. The imaging results show that the epiphyseal growth is mature;
✓. The defects or localized injuries of joint cartilage caused by trauma or other reasons;
✓. The injured area is the distal weight-bearing surface of the femoral condyle of the knee joint, with no more than 4 lesions, and there is no injury to the cruciate ligaments;
✓. The patients voluntarily sign and provide a written informed consent form and are willing to closely cooperate with the doctor's strict postoperative rehabilitation program.

Exclusion criteria

✕. The patient is extremely overweight, with a body mass index greater than 35;
✕. The lower limb alignment is valgus by more than 10° and varus by more than 5°;
✕. Multiple ligament injuries;
✕. There are numerous bad habits such as heavy smoking, drug abuse, and excessive alcohol consumption;
✕. Has undergone open knee joint surgery within the past six months;
✕. Has severe joint stiffness or fibrosis;
✕. Has an allergic constitution or a history of allergic reactions to collagen;
✕. Has mental abnormalities;

What they're measuring

KSS score

Timeframe: before the operation, at 3, 6, 12 and 24 months after the operation.

Trial details

NCT IDNCT07094100

SponsorThe First Affiliated Hospital of Xinxiang Medical College

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Wenjie Ren

8613937354075 13937354075@163.com

View on ClinicalTrials.gov More Cartilage Injury trials