CompletedNot Applicable

Mediation Analysis in Cardiac Surgery

China13,683 participantsStarted 2025-01-01

Plain-language summary

This study investigates the mediating role of intraoperative allogeneic red blood cell transfusion in the relationship between preoperative anaemia and postoperative complications in patients undergoing cardiac surgery. Using mediation analysis methods, we aim to determine whether and to what extent intraoperative transfusion explains the association between preoperative anaemia and adverse postoperative outcomes. By elucidating this pathway, the study seeks to inform perioperative blood management strategies and support more personalized, risk-adapted approaches to minimize postoperative complications in anaemic patients undergoing cardiac procedures.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18 and older ； * Undergoing elective cardiac surgery with cardiopulmonary bypass Exclusion Criteria: * preoperative mechanical circulatory support * ASA physical status VI-V * unplanned intra-hospital reoperations * catheter-based valve replacements, * heart tumours, * stent implantation surgeries, * coronary angiography, * transvascular valve clamping, * tetralogy of Fallot, * ventricular aneurysms, * cardiomyopathies,

What they're measuring

Incidence of Postoperative Complications

Timeframe: From the start of surgery to 30 days after surgery

Trial details

NCT IDNCT07092683

SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-05-01

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